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Article Dans Une Revue Science of the Total Environment Année : 2023

Medical devices used in NICU: The main source of plasticisers' exposure of newborns

Morgane Masse
  • Fonction : Auteur
Benoît Boeuf
  • Fonction : Auteur
Bertrand Decaudin
Nelly Durand
  • Fonction : Auteur
Stéphanie Genay
  • Fonction : Auteur
Céline Lambert
Jérémy Pinguet
Varlane Ponsonnaille
  • Fonction : Auteur
Damien Richard
  • Fonction : Auteur
Nathalie Saturnin
  • Fonction : Auteur
Laurent Storme
  • Fonction : Auteur

Résumé

Phthalates and other plasticisers are extensively used in medical devices (MD) from which they can leach out and lead to potential multiple problems for the patients. This exposure is a major issue because it is associated with reproductive and neurodevelopment disorders. The Neonatal Intensive Care Units (NICU) population is at high risk due to the daily intensive medical interventions, the reduced ability of newborns to remove these contaminants and their higher sensitivity to endocrine disruptors. We conducted a multicentric biomonitoring study to assess and compare the urinary levels of DEHP (di-(2-ethylhexyl)phthalate), DEHTP (di-(2-ethylhexyl)terephthalate) and TEHTM (tri-(2-ethylhexyl)trimellitate) metabolites as biomarkers of this exposure during and after the newborns' stay in NICU. Daily urinary samples were collected in NICU and at discharge from the hospital for each patient. MD sources and exposure factors were also investigated. 508 urinary samples from 97 patients enrolled in centres 1 and 2 (C1/C2) were collected. The exposure of newborns to DEHP was greater than that of DEHTP and TEHTM, with a median concentration of DEHP metabolites (C1:195.63 ng/mL;C2:450.87 ng/mL) respectively 5 to 10 times higher and 57 to 228 times higher than the median concentrations of DEHTP and TEHTM metabolites. The urinary concentrations of DEHP and TEHTM metabolites were significantly lower at discharge than in NICU, with a 18-and 35-fold decrease for DEHP and a 4 and 8-fold decrease for TEHTM, respectively for C1 and C2, but were similar for DEHTP metabolites. MD used for respiratory assistance, infusion therapy,enteral nutrition and transfusion were the main sources of exposure. Smaller gestational age and body weight significantly increased the newborns' exposure. The elevated levels of DEHP metabolites in NICU patients are still alarming. Additional efforts are necessary to promote its substitution in MD by possibly safer alternatives such as TEHTM and DEHTP, particularly when used for the care of newborns.

Dates et versions

hal-03982703 , version 1 (10-02-2023)

Identifiants

Citer

Lise Bernard, Morgane Masse, Benoît Boeuf, Philip Chennell, Bertrand Decaudin, et al.. Medical devices used in NICU: The main source of plasticisers' exposure of newborns. Science of the Total Environment, 2023, 858, pp.159994. ⟨10.1016/j.scitotenv.2022.159994⟩. ⟨hal-03982703⟩
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