Article Dans Une Revue Brain Research Année : 1998

Anti-opioid efficacy of Neuropeptide FF in morphine-tolerant mice

Résumé

The modulatory effects of 1DMe D-Tyr-Leu-NMe Phe-Gln-Pro-Gln-Arg-Phe-NH , an agonist of Neuropeptide FF NPFF 2 receptors, on opioid antinociceptive activity have been compared in naive and tolerant mice in the tail-flick and the hot-plate tests. In Ž . naive mice, 1DMe alone had no effect on pain threshold but decreased dose-dependently 3-22 nmol the analgesic activity of morphine Ž . in both tests. In tolerant mice, injections of 60-fold lower doses of 1DMe 0.05-0.5 nmol reverse morphine-induced analgesia in the Ž . tail-flick test but this anti-opioid effect was no longer observed with the highest doses of 1DMe tested 3-22 nmol . In the hot-plate test, the anti-opioid action of 1DMe was not detected, whatever doses tested. Neither the NPFF-like immunoreactivity content of spinal cord and of olfactory bulbs, nor the density of NPFF receptors in olfactory bulbs, were altered. These results indicate that a chronic morphine treatment modifies the pharmacological properties of NPFF but the type of pain test is crucial in determining NPFF effects.

Dates et versions

hal-04887775 , version 1 (22-01-2025)

Identifiants

Citer

Agathe Gelot, Bernard Frances, Anne Roussin. Anti-opioid efficacy of Neuropeptide FF in morphine-tolerant mice. Brain Research, 1998, 808 (2), pp.166-173. ⟨10.1016/s0006-8993(98)00665-9⟩. ⟨hal-04887775⟩
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