Preanalytical, analytical, gestational and pediatric aspects of the S100B immuno-assays
Résumé
Abstract Background: Traumatic brain injury management is a tricky issue in children and pregnant women (due to adverse effects of computer tomography). To facilitate management, we report the main analytical performances and reference ranges for blood tests for the well-established S100B biomarker in under-16 children on a DiaSorin Methods: Serum S100B concentrations were determined by chemiluminescent immunoassay on a DiaSorin Results: For children, four age-groups emerged, i.e. 0–3 months (mean: 0.97 μg/L; standard deviation (SD): 0.36; 95th percentile: 1.55), 4–9 months (mean: 0.58 μg/L; SD: 0.30; 95th: 1.18), 10–24 months (mean: 0.31 μg/L; SD: 0.12; 95th: 0.54) and 2–16 years (mean: 0.20 μg/L; SD: 0.07; 95th: 0.32). For pregnant women, serum S100B concentrations were similar to defined ranges for adults and not significantly different between trimesters on DiaSorin Conclusions: Data provided here is useful for interpreting serum S100B test results, in terms of preanalytical conditions, analytical performances, pediatric and pregnancy’ environment.