As a leading cause of disability worldwide, migraine is a neurovascular disorder characterized by headaches crisis and sensory hypersensitivities such as photophobia and/or allodynia. Migraine pathophysiology is complex and still partially understood. As a source of new findings, we use a novel brain neuroimaging modality that is particularly interesting for vascular diseases: the functional ultrasound imaging (fUSi). As an alternative to functional magnetic resonance imaging (fMRI), this modality of neuroimaging enables the measurement of cerebral blood volume with a high sensitivity and spatio-temporal resolution (100 µm and 1 ms, respectively). Due to the vascular aspect of the pathophysiological alterations previously ob- served in migraine patients, this study aims at deciphering the sequence of vascular dynamic changes on the whole brain and the trigeminovascular system in relevant animal models of migraine induced by systemic administrations of nitric oxide donors. This study adds new insights in migraine pathophysiology and proves the potential of fUS imaging as an important new technology to decipher nociceptive components of neurovascular diseases such as migraine.