Cholesterol-based α-phenyl-N-tert-butyl nitrone derivatives as antioxidants against light-induced retinal degeneration - Université Clermont Auvergne
Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 2010

Cholesterol-based α-phenyl-N-tert-butyl nitrone derivatives as antioxidants against light-induced retinal degeneration

Résumé

Two cholesterol-based α-phenyl-N-tert-butyl nitrone derivatives were synthesized as antioxidants against light-induced retinal degeneration. Whereas nitrone 10 significantly protected retina against bright fluorescent light exposure when injected into the vitreous at 1 mM, no protection was observed with nitrone 6. The parent compound α-phenyl-N-tert-butyl nitrone also exhibited protective activity at 9 mM but not at 1 mM. This suggests that nitrone 10 may be a candidate for the treatment of retinal diseases.

Dates et versions

hal-04610212 , version 1 (12-06-2024)

Identifiants

Citer

Fanny Choteau, Grégory Durand, Isabelle Ranchon-Cole, Christine Cercy, Bernard Pucci. Cholesterol-based α-phenyl-N-tert-butyl nitrone derivatives as antioxidants against light-induced retinal degeneration. Bioorganic and Medicinal Chemistry Letters, 2010, 20 (24), pp.7405-7409. ⟨10.1016/j.bmcl.2010.10.037⟩. ⟨hal-04610212⟩
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