In vitro study of bacterial adhesion and biofilm growth on fresh, frozen, or decellularized human bone grafts - Université Clermont Auvergne Accéder directement au contenu
Pré-Publication, Document De Travail Année : 2023

In vitro study of bacterial adhesion and biofilm growth on fresh, frozen, or decellularized human bone grafts

Guillaume Villatte
Guillaume Fassot
  • Fonction : Auteur
Roger Erivan
  • Fonction : Auteur
Stéphane Descamps
  • Fonction : Auteur
Yohann Wittrant
Stéphane Boisgard
  • Fonction : Auteur
Ousmane Traore
  • Fonction : Auteur

Résumé

There was no significant difference in bacterial adhesion between the 3 bone graft types tested, regardless of the bacterial strain used (p > 0.22). After 72 hours of culture, there was no significant difference between the Fresh and Frozen bone groups, while the number of CFU in the Decellularised group was significantly lower (p < 0.01), averaging -0.72 +/- 0.08 lg, -0.20 +/- 0.01 lg and -0.78 +/- 0.48 lg with S. epidermidis, S. aureus and E. coli respectively. Absolute values differences are low, and considering fresh bone (equivalent to autograft) as the gold standard due to its low infection rates in clinical studies, we can conclude that adhesion and biolfilm development characteristics are similar between Fresh, Frozen and Decellularised bone grafts..

Dates et versions

hal-04494533 , version 1 (07-03-2024)

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Citer

Guillaume Villatte, Guillaume Fassot, Roger Erivan, Jean-Marie Nedelec, Stéphane Descamps, et al.. In vitro study of bacterial adhesion and biofilm growth on fresh, frozen, or decellularized human bone grafts. 2024. ⟨hal-04494533⟩
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