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Article Dans Une Revue Journal of Molecular Liquids Année : 2024

Leaching of plasticizers from PVC medical devices: A molecular interpretation of experimental migration data

Résumé

High pressure liquid chromatography (HPLC) experiments and molecular simulations were combined to investigate the leaching process of DINCH, DEHT and TOTM plasticizers from PVC materials. Methodologies based on statistical thermodynamics were used to rationalize the migration of the different plasticizers in water and ethanolic solutions from different free energy contributions. We extended this combined approach to the study of the adsorption of a model drug (diazepam) on different plasticized-PVC materials. The drug loss by sorption was investigated in different solutions and rationalized at an energy level. The combination of experiments and theoretical approaches proved to be effective for these sophisticated systems and processes for which various energy contributions are involved.
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Dates et versions

hal-04406616 , version 1 (19-01-2024)

Licence

Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

Citer

Meriem Sahnoune Millot, Julien Devémy, Philip Chennell, Jérémy Pinguet, Alain Dequidt, et al.. Leaching of plasticizers from PVC medical devices: A molecular interpretation of experimental migration data. Journal of Molecular Liquids, 2024, 396, pp.123965. ⟨10.1016/j.molliq.2024.123965⟩. ⟨hal-04406616⟩
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