Social innovation through design in healthcare is an interdisciplinary and collaborative approach focused on co-creation and people. It relies on the involvement of multiple stakeholders to collectively reinvent the way we define health issues, to explore new ideas and experiment with innovative, sustainable solutions to resolve complex health problems. It is a lever for moving beyond the dominant paradigm of evidence-based medicine by mobilising participatory science and giving a space to local experiential knowledge. The examples given of two research programmes illustrate, on the one hand, the involvement of expert patients in the development and deployment of a project to enrich the breast cancer care pathway and, on the other, the value of local Livings Labs for collectively producing knowledge about the link of the food system with health, and imagining and testing action levers with all the stakeholders in a healthy food chain.