Luminescence depreciation is evidenced in ScVO4:Bi3+ at room temperature upon LED irradiation at 375 nm. The depreciation amounts 50% of the initial emission intensity after 13 h under a power density of 4.8 mW/cm2. The process is accelerated upon warming. These deleterious phenomena are explained by the photo-stimulated oxidization of Bi3+ that is favored in ScVO4:Bi3+ by the presence of lattice defects adjacent to Bi3+.