Maternal nutritional stress alters sperm competence in male mice offspring leading to reduced fertility - Université Clermont Auvergne Accéder directement au contenu
Pré-Publication, Document De Travail Année : 2021

Maternal nutritional stress alters sperm competence in male mice offspring leading to reduced fertility

Yuki Muranishi
  • Fonction : Auteur
Mélanie Vachette-Dit-Martin
  • Fonction : Auteur
Fabrice Saez
  • Fonction : Auteur
Pierre Sauvanet
  • Fonction : Auteur
David Volle
  • Fonction : Auteur
Serge Bottari
  • Fonction : Auteur
Francesca Carpentiero
  • Fonction : Auteur
Jessica Escoffier
  • Fonction : Auteur
Céline Jousse
Alain Bruhat
Julien Averous
Christophe Arnoult
  • Fonction : Auteur
Pierre Fafournoux

Résumé

Abstract Infertility represents a growing burden worldwide, with one in seven couples presenting difficulties conceiving. Amongst these, 10-15% of the men have idiopathic infertility that does not correlate with any defect in the classical sperm parameters measured. In the present study, we used a mouse model to investigate the effects of maternal undernutrition on fertility in male progeny. Our results indicate that mothers fed on a low protein diet during gestation and lactation produce male offspring with normal sperm morphology, concentration and motility but exhibiting an overall decrease of fertility when they reach adulthood. Particularly, sperm from these offspring show a remarkable lower capacity to fertilize oocytes when copulation occurs early in the estrus cycle relative to ovulation, due to an altered sperm capacitation. Our data demonstrate for the first time that maternal nutritional stress can have long-term consequences on the reproductive health of male progeny by affecting sperm physiology, especially capacitation, with no observable impact on spermatogenesis and classical quantitative and qualitative sperm parameters. Moreover, our experimental model could be of major interest to study, explain, and ultimately treat certain categories of infertilities.
Fichier principal
Vignette du fichier
2020.11.10.376616v1.full.pdf (1.42 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03434028 , version 1 (18-11-2021)

Identifiants

Citer

Yuki Muranishi, Laurent Parry, Mélanie Vachette-Dit-Martin, Fabrice Saez, Cécile Coudy-Gandilhon, et al.. Maternal nutritional stress alters sperm competence in male mice offspring leading to reduced fertility. 2021. ⟨hal-03434028⟩
44 Consultations
55 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More