Components of the anti-Müllerian hormone signaling pathway in gonads. - Université Clermont Auvergne Accéder directement au contenu
Article Dans Une Revue Molecular and Cellular Endocrinology Année : 2003

Components of the anti-Müllerian hormone signaling pathway in gonads.

N Di Clemente
  • Fonction : Auteur
N Josso
  • Fonction : Auteur
L Gouédard
  • Fonction : Auteur

Résumé

Anti-Müllerian hormone (AMH) is a member of the Transforming Growth Factor-beta (TGF-beta) family implicated in the regression of Müllerian ducts in male fetuses and in the development and function of gonads of both sexes. Members of the TGF-beta family signal through two types of serine/threonine kinase receptors called type I and type II, and two types of Smad proteins, receptor-regulated Smad (R-Smad) and common Smad, Smad4. Components of the AMH signaling pathway have been identified in gonads and gonadal cell lines. The AMH type II receptor is highly specific. In contrast, the identity of the AMH type I receptor is not clear; three type I receptors of Bone Morphogenetic Proteins (BMPs), Alk2, Alk3 and Alk6 may transduce AMH signals, but none of them has all the characteristics of an AMH type I receptor. AMH activates BMP-specific R-Smads and reporter genes.
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Dates et versions

hal-01930660 , version 1 (22-11-2018)

Identifiants

  • HAL Id : hal-01930660 , version 1
  • PUBMED : 14656470

Citer

N Di Clemente, N Josso, L Gouédard, C. Belville. Components of the anti-Müllerian hormone signaling pathway in gonads.. Molecular and Cellular Endocrinology, 2003, pp.9-14. ⟨hal-01930660⟩
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