Article Dans Une Revue Biology of the Cell Année : 2005

Activation of Mrc1, a mediator of the replication checkpoint, by telomere erosion

Résumé

In budding yeast, the loss of either telomere sequences (in telomerase-negative cells) or telomere capping (in mutants of two telomere end-protection proteins, Cdc13 and Yku) lead, by distinct pathways, to telomeric senescence. After DNA damage, activation of Rad53, which together with Chk1 represents a protein kinase central to all checkpoint pathways, normally requires Rad9, a checkpoint adaptor.

Dates et versions

hal-01919534 , version 1 (12-11-2018)

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Nathalie Grandin, Aymeric Bailly, Michel Charbonneau. Activation of Mrc1, a mediator of the replication checkpoint, by telomere erosion. Biology of the Cell, 2005, 97 (10), pp.799 - 814. ⟨10.1042/BC20040526⟩. ⟨hal-01919534⟩
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