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Article Dans Une Revue Endocrinology Année : 2012

Lxrα regulates the androgen response in prostate epithelium

Résumé

Benign prostatic hyperplasia is a nonmalignant enlargement of the prostate that commonly occurs in older men. We show that liver X receptor (Lxr)-α knockout mice (lxrα(-/-)) develop ventral prostate hypertrophy, correlating with an overaccumulation of secreted proteins in prostatic ducts and an alteration of vesicular trafficking in epithelial cells. In the fluid of the lxrα(-/-) prostates, spermine binding protein is highly accumulated and shows a 3000-fold increase of its mRNA. This overexpression is mediated by androgen hypersensitivity in lxrα(-/-) mice, restricted to the ventral prostate. Generation of chimeric recombinant prostates demonstrates that Lxrα is involved in the establishment of the epithelial-mesenchymal interactions in the mouse prostate. Altogether these results point out the crucial role of Lxrα in the homeostasis of the ventral prostate and suggest lxrα(-/-) mice may be a good model to investigate the molecular mechanisms of benign prostatic hyperplasia.

Domaines

Autre [q-bio.OT]
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Dates et versions

hal-01129772 , version 1 (28-05-2020)

Identifiants

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Emilie Viennois, Teresa Esposito, Julie Dufour, Aurélien Pommier, Stéphane Fabre, et al.. Lxrα regulates the androgen response in prostate epithelium. Endocrinology, 2012, 153 (7), pp.3211-3223. ⟨10.1210/en.2011-1996⟩. ⟨hal-01129772⟩
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