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Chapitre D'ouvrage Année : 2023

Legionella and mitochondria, an intriguing relationship

Résumé

Legionella pneumophila is the causative agent of Legionnaires’ disease, a severe pneumonia. L. pneumophila injects via a type-IV-secretion-system (T4SS) more than 300 bacterial proteins into macrophages, its main host cell in humans. Certain of these bacterial effectors target organelles in the infected cell and hijack multiple processes to facilitate all steps of the intracellular life cycle of this pathogen. In this review, we discuss the interplay between L. pneumophila, an intracellular bacterium fully armed with virulence tools, and mitochondria, the extraordinary eukaryotic organelles playing prominent roles in cellular bioenergetics, cell-autonomous immunity and cell death. We present and discuss key findings concerning the multiple interactions of L. pneumophila with mitochondria during infection and the mechanisms employed by T4SS effectors that target mitochondrial functions to subvert infected cells.
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pasteur-04132531 , version 1 (30-04-2024)

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Paternité - Pas d'utilisation commerciale

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Francisco Javier García-Rodríguez, Carmen Buchrieser, Pedro Escoll. Legionella and mitochondria, an intriguing relationship. Saverio Marchi - Marche Polytechnic University, Ancona, Italy; Lorenzo Galluzzi - Weill Cornell Medical College, New York, NY, United States. Mitochondria and Bacterial Pathogens Part A, 374, Elsevier Inc, pp.37-81, 2023, International Review of Cell and Molecular Biology, 978-0-323-99403-3. ⟨10.1016/bs.ircmb.2022.10.001⟩. ⟨pasteur-04132531⟩
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