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Synthesis and Biological Evaluation of New Quinoxaline Derivatives of ICF01012 as Melanoma-Targeting Probes

Emmanuel Moreau , Radhia El Aissi , Jianrong Liu , Sophie Besse , Damien Canitrot et al.
ACS Medicinal Chemistry Letters, 2014, 5 (5), pp.468 - 473. ⟨10.1021/ml400468x⟩
Journal articles hal-01677548v1

Design, Synthesis, Biological Evaluation, and Structure–Activity Relationships of Substituted Phenyl 4-(2-Oxoimidazolidin-1-yl)benzenesulfonates as New Tubulin Inhibitors Mimicking Combretastatin A-4

Emmanuel Moreau , Sébastien Fortin , Lianhu Wei , Jacques Lacroix , Marie-France Côté et al.
Journal of Medicinal Chemistry, 2011, 54 (13), pp.4559 - 4580. ⟨10.1021/jm200488a⟩
Journal articles hal-01677554v1
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A Photochemical Approach to Pyridopyrroloquinoline Derivatives as New Potential Anticancer Agents

Pierre-Jean Aragon , Ange-Désiré Yapi , Frédéric Pinguet , Jean-Michel Chezal , Jean-Claude Teulade et al.
Chemical and Pharmaceutical Bulletin, 2004, 52, pp.659 - 663. ⟨10.1248/cpb.52.659⟩
Journal articles hal-02384520v1

N-Phenyl-N′-(2-chloroethyl)ureas (CEU) as potential antineoplastic agents. Part 2: Role of ω-hydroxyl group in the covalent binding to β-tubulin

Emmanuel Moreau , Sébastien Fortin , Alexandre Patenaude , Michel Desjardins , Jacques Lacroix et al.
Bioorganic and Medicinal Chemistry, 2007, 15 (3), pp.1430 - 1438. ⟨10.1016/j.bmc.2006.11.005⟩
Journal articles hal-01677583v1

A comparative molecular field and comparative molecular similarity indices analyses (CoMFA and CoMSIA) of N-phenyl-N′-(2-chloroethyl)ureas targeting the colchicine-binding site as anticancer agents

Emmanuel Moreau , Sébastien Fortin , Philippe Labrie , Lianhu Wei , Lakshmi P Kotra et al.
Bioorganic and Medicinal Chemistry, 2008, 16 (4), pp.1914 - 1926. ⟨10.1016/j.bmc.2007.11.004⟩
Journal articles hal-01677579v1

Mechanism of action of N-phenyl-N′-(2-chloroethyl)ureas in the colchicine-binding site at the interface between α- and β-tubulin

Emmanuel Moreau , Sébastien Fortin , Lianhu Wei , Philippe Labrie , Éric Petitclerc et al.
Bioorganic and Medicinal Chemistry, 2009, 17 (10), pp.3690 - 3697. ⟨10.1016/j.bmc.2009.03.056⟩
Journal articles hal-01677570v1
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A Novel HPLC Method for Direct Detection of Nitric Oxide Scavengers from Complex Plant Matrices and Its Application to Aloysia triphylla Leaves

Didier Fraisse , Alexandra Degerine-Roussel , Alexis Bred , Samba Ndoye , Magali Vivier et al.
Molecules, 2018, 23 (7), pp.1574. ⟨10.3390/molecules23071574⟩
Journal articles hal-01873226v1

Inhibition profiles of mono- and polyvalent FimH antagonists against 10 different Escherichia coli strains

T. Chalopin , Y. Brissonnet , Adeline Sivignon , D. Deniaud , L. Cremet et al.
Organic & Biomolecular Chemistry, 2015, 13 (46), pp.11369 - 11375. ⟨10.1039/c5ob01581b⟩
Journal articles hal-01931394v1
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Elaboration et caractérisation d’un hybride organominéral à base de polycaprolactone et de bioverre sous forme de mousse macroporeuse pour la régénération osseuse

Cédric Bossard
Chimie thérapeutique. Université Clermont Auvergne [2017-2020], 2018. Français. ⟨NNT : 2018CLFAC068⟩
Theses tel-02128441v1

Expeditious Synthesis of the Topoisomerase I Inhibitors Isoindolo[2,1-b]isoquinolin-7(5H)-one and the Alkaloid Rosettacin Based on Aryl Radical Cyclization of Enamide Generated by Using N-Acyl­iminium Chemistry

Ata Martin Lawson , Lahssen El Blidi , Aurélie Namoune , Alexandre Bridoux , Vijaykumar Nimbarte et al.
Synthesis: Journal of Synthetic Organic Chemistry, 2015, 47 (22), pp.3583-3592. ⟨10.1055/s-0034-1378811⟩
Journal articles hal-02332633v1

Imidazonaphthyridine systems (part 2): Functionalization of the phenyl ring linked to the pyridine pharmacophore and its replacement by a pyridinone ring produces intriguing differences in cytocidal activity

Emmanuel Moreau , Nicolas Masurier , Eric Debiton , Alicia Jacquemet , Antoine Bussière et al.
European Journal of Medicinal Chemistry, 2012, 52, pp.137 - 150. ⟨10.1016/j.ejmech.2012.03.011⟩
Journal articles hal-01677549v1
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Heteropolysaccharides from S. cerevisiae show anti-adhesive properties against E. coli associated with Crohn’s disease

Adeline Sivignon , Shin-Yi Yu , Nathalie Ballet , Pascal Vandekerckove , Nicolas Barnich et al.
Carbohydrate Polymers, In press, 271, pp.118415. ⟨10.1016/j.carbpol.2021.118415⟩
Journal articles hal-03373401v1

Linker structure-activity relationships in fluorodeoxyglucose chlorambucil conjugates for tumor-targeted chemotherapy

Valérie Weber , Mostafa El Hilali , Bastien Reux , Eric Debiton , Fernand Leal et al.
Bioorganic and Medicinal Chemistry, 2017, 25 (20), pp.5692 - 5708. ⟨10.1016/j.bmc.2017.08.043⟩
Journal articles hal-01677115v1

Characterization of the Covalent Binding of N-Phenyl-N'-(2-chloroethyl)ureas to -Tubulin: Importance of Glu198 in Microtubule Stability

Emmanuel Moreau , S. Fortin , B. Bouchon , C. Chambon , J. Lacroix et al.
Journal of Pharmacology and Experimental Therapeutics, 2011, 336 (2), pp.460 - 467. ⟨10.1124/jpet.110.171082⟩
Journal articles hal-01677562v1

N-Substituted 4-aminobenzamides (procainamide analogs): an assessment of multiple cellular effects vis-a-vis ion trapping

Emmanuel Moreau , G. Morissette
Molecular Pharmacology, 2008, ⟨10.1124/mol.105.016527⟩
Journal articles hal-01677587v1

Optimized N-phenyl-N′-(2-chloroethyl)ureas as potential antineoplastic agents: Synthesis and growth inhibition activity

Emmanuel Moreau , Sébastien Fortin , Michel Desjardins , Jean L C Rousseau , Eric Petitclerc et al.
Bioorganic and Medicinal Chemistry, 2005, 13 (24), pp.6703 - 6712. ⟨10.1016/j.bmc.2005.07.048⟩
Journal articles hal-01677590v1

Heterocyclization of Functionalized Vinylic Derivatives of Imidazo[1,2- a ]pyridines

Emmanuel Moreau , Jean Chezal , Gregory Delmas , Alain Gueiffier , Yves Blache et al.
Journal of Organic Chemistry, 2001, 66 (20), pp.6576 - 6584. ⟨10.1021/jo015582x⟩
Journal articles istex hal-01677665v1

Black mamba venom peptides target acid-sensing ion channels to abolish pain

Sylvie Diochot , Anne Baron , Miguel Salinas , Dominique Douguet , Sabine Scarzello et al.
Nature, 2012, 490 (7421), pp.552-555. ⟨10.1038/nature11494⟩
Journal articles istex hal-02115775v1
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Current Opinion on Chitosan and its Derivatives: Biological Impact in Antimicrobial Applications From Nature to Chitosan and It Derivatives: How it is Working?

Cédric Delattre
Advances in Biotechnology & Microbiology, 2017, 6 (2), ⟨10.19080/AIBM.2017.06.555684⟩
Journal articles hal-01657856v1
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Effect of proteases against biofilms of Staphylococcus aureus and Staphylococcus epidermidis

Pierre-Henri Elchinger , C. Delattre , S. Faure , O. Roy , S. Badel et al.
Letters in Applied Microbiology, 2014, 59 (5), pp.507-513. ⟨10.1111/lam.12305⟩
Journal articles hal-01081362v1

Synthesis of Polyfused Heterocycle Derivatives Containing the Dipyridoimidazole Core by Friedländer’s Reaction: Access to Analogs of Ellipticine

Emmanuel Moreau , Jean-Claude Teulade , Nicolas Desbois , Jean-Michel J.-M. Chezal , Florence Fauvelle et al.
Heterocycles, 2005, 65 (5), ⟨10.3987/COM-05-10354⟩
Journal articles hal-01677674v1
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Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation of ionotropic glutamate receptor subtypes 5, 6, and 7.

Emmanuelle Sagot , Darryl S. Pickering , Xiasui Pu , Michelle Umberti , Tine B. Stensbol et al.
Journal of Medicinal Chemistry, 2008, 51, pp.4093-4103
Journal articles hal-00323861v1
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Pharmacological characterization of (4R)-alkyl glutamate analogues at the ionotropic glutamate receptors - Focus on subtypes iGluR5-7

Lennart Bunch , Thierry Gefflaut , Sébastien Alaux , Emmanuelle Sagot , Brigitte Nielsen et al.
European Journal of Pharmacology, 2009, 609, pp.1-4
Journal articles hal-00376953v1
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Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of pyrrolo[3,4-a]carbazole-1,3-diones, pyrrolo[3,4-c]carbazole-1,3-diones, and 2-aminopyridazino[3,4-a]pyrrolo[3,4-c]carbazole-1,3,4,7-tetraone

Elisabeth Conchon , Fabrice Anizon , Bettina Aboab , Roy Golsteyn , Stéphane Leonce et al.
European Journal of Medicinal Chemistry, 2008, 43, pp.282-292
Journal articles hal-00255899v1
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Metabolic and Anti-Inflammatory Protective Properties of Human Enriched Serum Following Artichoke Leaf Extract Absorption: Results from an Innovative Ex Vivo Clinical Trial

Fabien Wauquier , Line Boutin-Wittrant , Aurélien Viret , Laure Guilhaudis , Hassan Oulyadi et al.
Nutrients, 2021, 13 (8), pp.2653. ⟨10.3390/nu13082653⟩
Journal articles hal-03326084v1
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Gliotransmission and Brain Glucose Sensing: Critical Role of Endozepines

Damien Lanfray , Sébastien Arthaud , Johanne Ouellet , Vincent Compère , Jean-Luc Do Rego et al.
Diabetes, 2013, 62 (3), pp.801-810. ⟨10.2337/db11-0785⟩
Journal articles hal-01962799v1

Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice

Damien Lanfray , Alexandre Caron , Marie-Claude Roy , Mathieu Laplante , Fabrice Morin et al.
Journal articles hal-01962802v1

Massive Cell Vacuolization Induced by Organic Amines Such as Procainamide

Emmanuel Moreau , G. Morissette
Journal of Pharmacology and Experimental Therapeutics, 2004, 310 (1), pp.395 - 406. ⟨10.1124/jpet.104.066084⟩
Journal articles hal-01677592v1
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Benefits of the ipowder® extraction process applied to Melissa officinalis L.: improvement of antioxidant activity and in vitro gastro-intestinal release profile of rosmarinic acid

Valérie Bardot , Anaïs Escalon , Isabelle Ripoche , Sylvain Denis , Monique Alric et al.
Food and Function, 2020, 11 (1), pp.722-729. ⟨10.1039/c9fo01144g⟩
Journal articles hal-02441644v1

Novel imidazo[1,2-a]naphthyridinic systems (part 1): Synthesis, antiproliferative and DNA-intercalating activities

Emmanuel Moreau , Mounir Andaloussi , Nicolas Masurier , Jacques Lacroix , René C Gaudreault et al.
European Journal of Medicinal Chemistry, 2008, 43 (11), pp.2505 - 2517. ⟨10.1016/j.ejmech.2008.02.017⟩
Journal articles istex hal-01677576v1