Increased BRCA1 protein in mammary tumours of rats fed marine omega-3 fatty acids. - Université Clermont Auvergne Accéder directement au contenu
Article Dans Une Revue Oncology Reports Année : 2007

Increased BRCA1 protein in mammary tumours of rats fed marine omega-3 fatty acids.

Résumé

Any factor affecting BRCA gene regulation may be of interest in the prevention of breast tumourigenesis. We studied the influence of dietary docosahexaenoic acid (DHA), a major omega-3 fatty acid present in marine products, on rat autochthonous mammary tumourigenesis. DHA-supplementation significantly reduced the incidence of tumours (30%, P=0.007) and led to a 60% increase (P=0.02) in BRCA1 protein level. Since DHA influences the product of a major tumour suppressor gene, this finding may contribute to the observation that high-fish consumption reduces the risk of breast cancer.
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Dates et versions

inserm-00149725 , version 1 (28-05-2007)

Identifiants

  • HAL Id : inserm-00149725 , version 1
  • PUBMED : 17342305

Citer

Marie-Lise Jourdan, Karine Mahéo, Aurélia Barascu, Caroline Goupille, Monique Peffault de Latour, et al.. Increased BRCA1 protein in mammary tumours of rats fed marine omega-3 fatty acids.. Oncology Reports, 2007, 17 (4), pp.713-9. ⟨inserm-00149725⟩
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