P23H and S334ter opsin mutations: Increasing photoreceptor outer segment n-3 fatty acid content does not affect the course of retinal degeneration. - Université Clermont Auvergne
Article Dans Une Revue Molecular Vision Année : 2004

P23H and S334ter opsin mutations: Increasing photoreceptor outer segment n-3 fatty acid content does not affect the course of retinal degeneration.

Résumé

The n-3 polyunsaturated fatty acids (PUFA) facilitate retinal development and function. Rats carrying transgenes with P23H and S334ter rhodopsin mutations lose their photoreceptors and have lower levels of 22:6n-3 in rod photoreceptor outer segments (ROS) than wild type (WT) animals. We tested the hypothesis that the rate of retinal degeneration in these mutant animals could be sensitive to the n-3 fatty acid content of retina.
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Dates et versions

hal-04610188 , version 1 (12-06-2024)

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  • HAL Id : hal-04610188 , version 1
  • PUBMED : 15064683

Citer

Rex Martin, Isabelle Ranchon-Cole, Richard Brush, Clint Williamson, Steven Hopkins, et al.. P23H and S334ter opsin mutations: Increasing photoreceptor outer segment n-3 fatty acid content does not affect the course of retinal degeneration.. Molecular Vision, 2004, 10, pp.199-207. ⟨hal-04610188⟩

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