Reinforcing effect of tramadol in the rat - Université Clermont Auvergne Accéder directement au contenu
Article Dans Une Revue Neuroscience Letters Année : 2023

Reinforcing effect of tramadol in the rat

Hend Omara-Reda
  • Fonction : Auteur
Omar Ouachikh
  • Fonction : Auteur
Dhouha Hamdi
  • Fonction : Auteur
Mohamed Lashin
  • Fonction : Auteur
Aziz Hafidi

Résumé

Tramadol is one of the most commonly prescribed analgesic opioids in various pharmacopeias. Tramadol has been linked to abuse in recent clinical investigations. However, the behavioral effects and neural substrates of the drug have not been well characterized in preclinical studies. As a result, the present study investigated the effects of tramadol on behavioral sensitizations in rats. Its impacts on cellular and molecular alterations in the brain were also investigated. In conditioned place preference (CPP) paradigm, tramadol induced behavioral as well as motor sensitizations. These effects were dramatically reduced by intraperitoneal administration of naltrexone, an opioid receptor antagonist. Tramadol caused changes in several molecular markers (pERK1/2, Δ-FosB, PKCγ, PKMζ GAD67) in the anterior cingulate cortex, which could indicate an increase in excitation within this structure. Tramadol is demonstrated in the present study to be a reinforcing drug in rats, as it increased both behavioral and motor sensitizations. Tramadol’s effects are most likely due to the high levels of excitation it causes in the brain, which is mostly caused by the activation of opioid receptors.
Fichier principal
Vignette du fichier
Reinforcing effect of tramadol in the rat-HAL(1).pdf (975.96 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Licence : CC BY NC ND - Paternité - Pas d'utilisation commerciale - Pas de modification

Dates et versions

hal-03936288 , version 1 (12-01-2023)

Licence

Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

Citer

Hend Omara-Reda, Omar Ouachikh, Dhouha Hamdi, Mohamed Lashin, Aziz Hafidi. Reinforcing effect of tramadol in the rat. Neuroscience Letters, 2023, 796, pp.137053. ⟨10.1016/j.neulet.2023.137053Get⟩. ⟨hal-03936288⟩
45 Consultations
81 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More