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Article Dans Une Revue Current Oncology Année : 2022

DTI Abnormalities Related to Glioblastoma: A Prospective Comparative Study with Metastasis and Healthy Subjects

Youssef El Ouadih
  • Fonction : Auteur
Bruno Pereira
Béatrice Claise
  • Fonction : Auteur
Rémi Chaix
  • Fonction : Auteur
Pierre Verrelle
  • Fonction : Auteur
Toufik Khalil
  • Fonction : Auteur
Jean-Jacques Lemaire

Résumé

(1) Background: Glioblastoma multiforme (GBM) shows complex mechanisms of spreading of the tumor cells, up to remote areas, and little is still known of these mechanisms, thus we focused on MRI abnormalities observable in the tumor and the brain adjacent to the lesion, up to the contralateral hemisphere, with a special interest on tensor diffusion imaging informing on white matter architecture; (2) Material and Methods: volumes, macroscopic volume (MV), brain-adjacent-tumor (BAT) volume and abnormal color-coded DTI volume (aCCV), and region-of-interest samples (probe volumes, ipsi, and contra lateral to the lesion), with their MRI characteristics, apparent diffusion coefficient (ADC), fractional anisotropy (FA) values, and number of fibers (DTI fiber tracking) were analyzed in patients suffering GBM (n = 15) and metastasis (n = 9), and healthy subjects (n = 15), using ad hoc statistical methods (type I error = 5%) (3) Results: GBM volumes were larger than metastasis volumes, aCCV being larger in GBM and BAT ADC was higher in metastasis, ADC decreased centripetally in metastasis, FA increased centripetally either in GBM or metastasis, MV and BAT FA values were higher in GBM, ipsi FA values of GBM ROIs were higher than those of metastasis, and the GBM ipsi number of fibers was higher than the GBM contra number of fibers; (4) Conclusions: The MV, BAT and especially the aCCV, as well as their related water diffusion characteristics, could be useful biomarkers in oncology and functional oncology.

Dates et versions

hal-03889471 , version 1 (08-12-2022)

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Citer

Youssef El Ouadih, Bruno Pereira, Julian Biau, Béatrice Claise, Rémi Chaix, et al.. DTI Abnormalities Related to Glioblastoma: A Prospective Comparative Study with Metastasis and Healthy Subjects. Current Oncology, 2022, 29 (4), pp.2823-2834. ⟨10.3390/curroncol29040230⟩. ⟨hal-03889471⟩
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