Hematopoietic stem cell transplantation for acute lymphoblastic leukemia: why do adolescents and young adults outcomes differ from those of children? A retrospective study on behalf of the Francophone Society of Stem Cell Transplantation and Cellular Therapy (SFGM-TC) - Université Clermont Auvergne Accéder directement au contenu
Article Dans Une Revue Journal of Cancer Research and Clinical Oncology Année : 2023

Hematopoietic stem cell transplantation for acute lymphoblastic leukemia: why do adolescents and young adults outcomes differ from those of children? A retrospective study on behalf of the Francophone Society of Stem Cell Transplantation and Cellular Therapy (SFGM-TC)

Fanny Rialland-Battisti
  • Fonction : Auteur
Patrice Chevallier
  • Fonction : Auteur
Nicolas Blin
  • Fonction : Auteur
Nathalie Dhédin
  • Fonction : Auteur
Regis Peffault de Latour
  • Fonction : Auteur
Cécile Pochon
  • Fonction : Auteur
Anne Sirvent
  • Fonction : Auteur
Charlotte Jubert
  • Fonction : Auteur
Edouard Forcade
  • Fonction : Auteur
Ana Berceanu
  • Fonction : Auteur
Pascale Schneider
  • Fonction : Auteur
Jacques-Olivier Bay
  • Fonction : Auteur
  • PersonId : 1069255
Pierre-Simon Rohrlich
  • Fonction : Auteur
Eolia Brissot
Catherine Paillard
  • Fonction : Auteur
Dominique Plantaz
  • Fonction : Auteur
Stéphanie Nguyen Quoc
  • Fonction : Auteur
Natacha Maillard
  • Fonction : Auteur
Lucie Planche
  • Fonction : Auteur

Résumé

Purpose: In the acute lymphoblastic leukemia (ALL) landscape, adolescents and young adults (AYA) often present high-risk diseases and increased chemotherapy-related toxicity. Studies analyzing the outcomes of AYA after hematopoietic stem cell transplantation (HSCT) are scarce. Our study aimed to compare the outcomes of children and AYA with ALL after HSCT and to determine the factors influencing potential differences.Method: 891 patients, from the SFGM-TC registry, aged between 1 and 25 years who received HSCT between 2005 and 2012 were included. The outcomes of AYA were compared to the ones of their younger counterparts.Results: Five-year OS and GRFS were lower in AYA: 53.1% versus 64% and 36% versus 47% (p = 0.0012 and p = 0.007, respectively). WhileCIR was similar in both groups, 5 year-treatment related mortality was higher in AYA: 19% versus 13% (p = 0.04). The lower GRFS in AYA was mainly explained by a higher chronic graft versus host disease (cGvHD) incidence: 32% versus 19% (p < 0.001). Use of peripheral blood stem cells and use of anti-thymoglobulin appeared to be the main factors impacting cGvHD occurrence in AYA.Conclusion: AYA have worse outcomes than children after HSCT for ALL because of a greater risk of TRM due to cGvHD. HSCT practices should be questioned in this population.Keywords: Acute lymphoblastic leukemia; Adolescents and young adults; Graft versus host disease; Hematopoietic stem cell transplantation.

Dates et versions

hal-03737646 , version 1 (25-07-2022)

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Audrey Grain, Fanny Rialland-Battisti, Patrice Chevallier, Nicolas Blin, Jean-Hugues Dalle, et al.. Hematopoietic stem cell transplantation for acute lymphoblastic leukemia: why do adolescents and young adults outcomes differ from those of children? A retrospective study on behalf of the Francophone Society of Stem Cell Transplantation and Cellular Therapy (SFGM-TC). Journal of Cancer Research and Clinical Oncology, 2023, 149 (4), pp.1473-1483. ⟨10.1007/s00432-022-04021-1⟩. ⟨hal-03737646⟩
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