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Article Dans Une Revue Journal of Oral Medicine and Oral Surgery Année : 2021

Salivary diagnosis of oral cancers by salivary samples: a systematic literature review

Marine Guillon
  • Fonction : Auteur
Nathalie Pham Dang
Joannice Thévenon
  • Fonction : Auteur
Laurent Devoize

Résumé

The aim of this article is to carry out a systematic analysis of the literature concerning the diagnosis of oral cancers by salivary samples. Different biomarkers, produced by the tumor itself or by its environment, show significant variations in their concentration at the salivary level, correlated or not at the blood or tissue level. After studying 239 articles, we included 36 in this analysis. This allowed us to extract 46 potential molecules for salivary diagnostics. Only 26 demonstrated a good level of evidence. 8 clusters have also been proposed for better specificity and sensitivity. To date, the protocols of the studies carried out do not allow to affirm that one or more biomarkers are effective for a salivary diagnosis of oral cancers. Part of the results contradict or sometimes lack precision. In addition, the studies included here do not have a good methodological quality and do not always take into account other factors influencing the concentrations (systemic diseases, age, sex, tobacco, alcohol, etc .). Additional studies are still necessary, notably with larger groups of patients, representative of the general population and standardization of the protocols for the study and quantification of biomarkers.

Dates et versions

hal-03703664 , version 1 (24-06-2022)

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Citer

Marine Guillon, Nathalie Pham Dang, Joannice Thévenon, Laurent Devoize. Salivary diagnosis of oral cancers by salivary samples: a systematic literature review. Journal of Oral Medicine and Oral Surgery, 2021, 27 (3), pp.39. ⟨10.1051/mbcb/2021013⟩. ⟨hal-03703664⟩
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