Top-down Versus Step-up Strategies to Prevent Postoperative Recurrence in Crohn’s Disease - Université Clermont Auvergne Accéder directement au contenu
Article Dans Une Revue Inflammatory Bowel Diseases Année : 2023

Top-down Versus Step-up Strategies to Prevent Postoperative Recurrence in Crohn’s Disease

Résumé

Abstract Background The best management after ileocolonic resection is still unknown in Crohn’s disease (CD). We compared step-up and top-down approaches to prevent short and long-term postoperative recurrences in CD patients. Methods From a comprehensive database, consecutive CD patients who underwent intestinal resection (2014-2021) were included. Top-down (biologics started within the first month after surgery) or step-up strategies (no biologic between surgery and colonoscopy at 6 months) were performed with systematic colonoscopy at 6 months and therapeutic escalation if Rutgeerts index was ≥i2a (endoscopic postoperative recurrence). Propensity score analysis was applied for each comparison. Results Among 115 CD patients, top-down was the most effective strategy to prevent endoscopic postoperative recurrence (46.8% vs 65.9%, P = .042) and to achieve complete endoscopic remission (Rutgeerts index = i0; 45.3% vs 19.3%; P = .004) at 6 months. We did not observe any significant difference between the 2 groups regarding clinical postoperative recurrence (hazard ratio [HR], .86 [0.44-1.66], P = .66) and progression of bowel damage (HR, 0.81 [0.63-1.06], P = .12). Endoscopic postoperative recurrence at 6 months was associated with increased risk of clinical postoperative recurrence (HR, 1.97 [1.07-3.64], P 0.029) and progression of bowel damage (HR, 3.33 [1.23-9.02], P = .018). Among the subgroup without endoscopic postoperative recurrence at 6 months, the risks of clinical postoperative recurrence and progression of bowel damage were significantly improved in the top-down group (HR, 0.59 [0.37-0.94], P = .025; and HR, 0.73 [0.63-0.83], P < .001, respectively). Conclusions Top-down strategy should be the preferred management to prevent short and long-term postoperative recurrence in CD. Lay Summary Our data suggest that top-down strategy should be preferred to step-up approach to prevent endoscopic postoperative recurrence, as well as clinical postoperative recurrence and progression of bowel damage in most of the patients with Crohn's disease after bowel resection.
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Dates et versions

hal-03662148 , version 1 (09-05-2022)

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Paternité - Pas d'utilisation commerciale

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Anthony Buisson, Lysa Blanco, Luc Manlay, Maud Reymond, Michel Dapoigny, et al.. Top-down Versus Step-up Strategies to Prevent Postoperative Recurrence in Crohn’s Disease. Inflammatory Bowel Diseases, 2023, 29 (2), pp.185-194. ⟨10.1093/ibd/izac065⟩. ⟨hal-03662148⟩
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