Proneness of TLR5 deficient mice to develop colitis is microbiota dependent - Université Clermont Auvergne Accéder directement au contenu
Article Dans Une Revue Gut microbes Année : 2015

Proneness of TLR5 deficient mice to develop colitis is microbiota dependent

Résumé

Alterations in the gut microbiota have been implicated to play a role in potentiating inflammatory bowel diseases in both humans and mice. Mice lacking the flagellin receptor, toll-like receptor 5 (TLR5), are prone to develop spontaneous gut inflammation, but are significantly protected when treated with antibiotics or maintained in germ-free conditions. However, given that the incidence of spontaneous inflammation in TLR5KO mice is quite variable in conventional conditions (typically ∼10% show clear colitis), this result is far from definitive and does not rule out that TLR5KO mice might be prone to develop inflammation even in the absence of a microbiota. Herein, we demonstrate that neutralization of IL10 signaling induces colitis in 100% of TLR5KO mice which provide a more rigorous approach to evaluate the role of microbiota in gut inflammation. Mice treated with antibiotics or maintained in germ-free condition are substantially protected against IL-10R neutralization-induced colitis, underscoring that gut inflammation in TLR5KO mice is dependent upon the presence of a gut microbiota.
Fichier principal
Vignette du fichier
Singh V., 2015 (Gut Microbes).pdf (698.34 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03516833 , version 1 (07-01-2022)

Licence

Paternité - Pas de modifications

Identifiants

Citer

Vishal Singh, Beng San Yeoh, Frédéric Antonio Carvalho, Andrew T Gewirtz, Matam Vijay-Kumar. Proneness of TLR5 deficient mice to develop colitis is microbiota dependent. Gut microbes, 2015, 6 (4), pp.279-283. ⟨10.1080/19490976.2015.1060390⟩. ⟨hal-03516833⟩
40 Consultations
53 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More