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Communication Dans Un Congrès Année : 2021

How to reduce Sarcopenia in the Undernourished Elderly: Enrichment of Food with “Energy Saver” Probiotics

Giron Muriel
Muriel Thomas
Stéphanie Bornes
  • Fonction : Auteur
  • PersonId : 1207298
Marianne Jarzaguet
Camille Mayeur
Dominique Dardevet

Résumé

The population over 60 years could represent 35% of the French population in 30 years and at least 30% of them suffer from sarcopenia and undernutrition. Various strategies exist to limit sarcopenia, but they can be unsuitable for frail people. Indeed, frail individuals present a decreased efficiency for food energy use associated with an alteration of their gut microbiota. In addition, as frail people are generally sitting (with a minimum exercise), they can be non-compliant to physical exercise advices. Other strategies to limit sarcopenia in this population should be developed and in particular novel nutritional recommendations/strategies. Probiotics are known to be able to modulate the composition of the microbiota and provide other health benefits. The aim of my thesis is then to investigate the potential of a probiotic strain to limit muscle mass loss in frail elderly population. Previous work from collaborators of the project have shown that when transferred to axenic mice, the microbiota from intestine-resected patient led to an increased release of GLP-1 and Ghrelin in rats, 2 peptides involved in appetite regulation of increased insulin sensitivity. We therefore postulated that specific microbes selected from these patients and further given to frail patients could modulate/alter gut peptides synthesis, increase insulin sensitivity and limit muscle mass loss. Selected bacterial strains isolated from an intestine-resected patient were screened in vitro for their ability to stimulate the secretion of gut peptides (GLP-1) in enterocytes and on Caenorhabditis elegans for their effect on worm longevity. The impact of probiotic microbes was assessed on protein-energy metabolism and insulin-sensitivity in old rats subjected to dietary restriction (to mimic frailty in humans). The results cannot be detailed in the present abstract since a patent deposit is pending concerning the strains and related health effects. We hope that the patent will be finalized for poster or oral presentation within the next months. The ultimate objective of my thesis will be to incorporate the most promising selected probiotic strain into a fermented food (soft cheese) in order to combine the beneficial effects on the metabolism of the strain with high protein intakes, this latter being also insufficiently supplied in frail elderly population.
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Dates et versions

hal-03456032 , version 1 (01-12-2021)

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  • HAL Id : hal-03456032 , version 1

Citer

Giron Muriel, Muriel Thomas, Stéphanie Bornes, Marianne Jarzaguet, Camille Mayeur, et al.. How to reduce Sarcopenia in the Undernourished Elderly: Enrichment of Food with “Energy Saver” Probiotics. Journées de l'Ecole Doctorale ED65, 2021, CLERMONT- FERRAND, France. ⟨hal-03456032⟩
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