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Article Dans Une Revue Archives of Otolaryngology Head and Neck Surgery Année : 2021

Prognosis in Head and Neck Cancer: Importance of Nutritional and Biological Inflammatory Status

Nicolas Saroul
Mathilde Puechmaille
  • Fonction : Auteur
Céline Lambert
Achraf Sayed Hassan
  • Fonction : Auteur
Michel Lapeyre
  • Fonction : Auteur
Thierry Mom
Maureen Bernadach
  • Fonction : Auteur
Laurent Gilain
  • Fonction : Auteur

Résumé

Objectives To determine the importance of nutritional status, social status, and inflammatory status in the prognosis of head and neck cancer. Study Design Single-center retrospective study of prospectively collected data. Setting Tertiary referral center. Methods Ninety-two consecutive patients newly diagnosed for cancer of the upper aerodigestive tract without metastases were assessed at time of diagnosis for several prognostic factors. Nutritional status was assessed by the nutritional risk index, social status by the EPICES score, and inflammatory status by the systemic inflammatory response index. The primary endpoint was overall survival. Results In multivariable analysis, the main prognostic factors were the TNM classification (hazard ratio [HR] = 3.34, P = .002, for stage T3-4), malnutrition as assessed by the nutritional risk index (HR = 3.64, P = .008, for severe malnutrition), and a systemic inflammatory response index score ≥1.6 (HR = 3.32, P = .02). Social deprivation was not a prognostic factor. Conclusion Prognosis in head and neck cancer is multifactorial; however, malnutrition and inflammation are important factors that are potentially reversible by early intervention.
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Dates et versions

hal-03345331 , version 1 (15-09-2021)

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Citer

Nicolas Saroul, Mathilde Puechmaille, Céline Lambert, Achraf Sayed Hassan, Julian Biau, et al.. Prognosis in Head and Neck Cancer: Importance of Nutritional and Biological Inflammatory Status. Archives of Otolaryngology Head and Neck Surgery, In press, pp.019459982110045. ⟨10.1177/01945998211004592⟩. ⟨hal-03345331⟩
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