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Article Dans Une Revue Emerging Topics in Life Sciences Année : 2018

Pyrrolysine in archaea: a 22nd amino acid encoded through a genetic code expansion

Résumé

The 22nd amino acid discovered to be directly encoded, pyrrolysine, is specified by UAG. Until recently, pyrrolysine was only known to be present in archaea from a methanogenic lineage (Methanosarcinales), where it is important in enzymes catalysing anoxic methyla-mines metabolism, and a few anaerobic bacteria. Relatively new discoveries have revealed wider presence in archaea, deepened functional understanding, shown remarkable carbon source-dependent expression of expanded decoding and extended exploitation of the pyrrolysine machinery for synthetic code expansion. At the same time, other studies have shown the presence of pyrrolysine-containing archaea in the human gut and this has prompted health considerations. The article reviews our knowledge of this fascinating exception to the 'standard' genetic code.
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Dates et versions

hal-02996724 , version 1 (09-11-2020)

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Paternité - Pas d'utilisation commerciale

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Jean-François Brugere, John F. Atkins, Paul W. O'Toole, Guillaume Borrel. Pyrrolysine in archaea: a 22nd amino acid encoded through a genetic code expansion. Emerging Topics in Life Sciences, 2018, 2 (4), pp.607 - 618. ⟨10.1042/etls20180094⟩. ⟨hal-02996724⟩
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