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Article Dans Une Revue Biochimie Année : 2008

Amino-acid limitation induces the GCN2 signaling pathway in myoblasts but not in myotubes

Résumé

There is a growing body of evidence that suggests that amino acids play an important role in controlling gene expression, but the cell specificity of the amino-acid-mediated regulation of gene expression in mammals remains unknown. Using a model of muscle cells (C2C12) at two stages of differentiation, i.e. myoblasts and myotubes, we employed transcriptional profiling to show that amino-acid deficiency does not regulate the same set of gene in differentiated and non-differentiated cells. Furthermore, in myotubes, the GCN2 pathway is not activated by amino-acid starvation due to an amino-acid supply from intracellular proteolysis associated with a low GCN2 expression.

Dates et versions

hal-02665914 , version 1 (31-05-2020)

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Christiane Deval, Jeremie Talvas, Cédric Chaveroux, Anne-Catherine Maurin, Sylvie Mordier, et al.. Amino-acid limitation induces the GCN2 signaling pathway in myoblasts but not in myotubes. Biochimie, 2008, 90 (11-12), pp.1716-1721. ⟨10.1016/j.biochi.2008.07.004⟩. ⟨hal-02665914⟩
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