Bowel wall healing assessed using magnetic resonance imaging predicts sustained clinical remission and decreased risk of surgery in Crohn’s disease - Université Clermont Auvergne Accéder directement au contenu
Article Dans Une Revue Journal of Gastroenterology Année : 2019

Bowel wall healing assessed using magnetic resonance imaging predicts sustained clinical remission and decreased risk of surgery in Crohn’s disease

Résumé

BackgroundEndoscopic mucosal healing is considered as the best therapeutic target in Crohn's disease (CD) as it is associated with better long-term outcomes. We investigated whether bowel wall healing (BWH) assessed using magnetic resonance imaging (MRI) could predict favorable outcomes and could be a potential therapeutic target.MethodsWe performed a post hoc analysis from two prospective studies (n=174 patients). All the patients with previous objective signs of bowel inflammation and assessed by MRI for therapeutic efficacy had a standardized and blinded evaluation, and underwent MRI. Complete BWH was defined as no segmental MaRIA>7 or no segmental Clermont score>8.4 and BWH as no segmental MaRIA>11 or no segmental Clermont score>12.5. Clinical corticosteroid-free remission (CFREM) was defined as no reappearance or worsening of clinical manifestation leading to therapeutic modification, hospitalization or CD-related surgery. Multivariate analyses were performed including all the relevant parameters.ResultsOverall, 63 patients with CD were included (mean follow-up=4.83.1 semesters). In multivariate analysis (n=303 semesters), complete BWH or BWH was associated with sustained CFREM according to MaRIA [OR=4.42 (2.29-26.54); p=0.042 and OR=3.43 (1.02-27.02); p=0.047, respectively] or Clermont score [OR=3.09 (1.01-12.91); p=0.049 and OR=3.88 (1.40-13.80); p=0.036, respectively]. In multivariate analysis (n=63 patients), complete BWH or BWH was associated with decreased risk of surgery using MaRIA [HR=0.16 (0.043-0.63); p=0.008 and HR=0.24 (0.07-0.77); p=0.017, respectively] or Clermont score [HR=0.24 (0.07-0.78); p=0.016 and HR=0.23 (0.07-0.76); p=0.016, respectively].Conclusions p id=Par4 MRI endpoints are predictive of favorable outcomes after medical therapy and could be used as therapeutic target in daily practice and clinical trials.
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Dates et versions

hal-02013727 , version 1 (11-02-2019)

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Anthony Buisson, Constance Hordonneau, Felix Goutorbe, Christophe Allimant, Marion Goutte, et al.. Bowel wall healing assessed using magnetic resonance imaging predicts sustained clinical remission and decreased risk of surgery in Crohn’s disease. Journal of Gastroenterology, 2019, 54 (4), pp.312-320. ⟨10.1007/s00535-018-1505-8⟩. ⟨hal-02013727⟩
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