Role of the liver X receptors in skin physiology: Putative pharmacological targets in human diseases. - Université Clermont Auvergne Accéder directement au contenu
Article Dans Une Revue Chemistry and Physics of Lipids Année : 2017

Role of the liver X receptors in skin physiology: Putative pharmacological targets in human diseases.

Résumé

Liver X receptors (LXRs) are members of the nuclear receptor superfamily that have been shown to regulate various physiological functions such as lipid metabolism and cholesterol homeostasis. Concordant reports have elicited the possibility to target them to cure many human diseases including arteriosclerosis, cancer, arthritis, and diabetes. The high relevance of modulating LXR activities to treat numerous skin diseases, mainly those with exacerbated inflammation processes, contrasts with the lack of approved therapeutic use. This review makes an assessment to sum up the findings regarding the physiological roles of LXRs in skin and help progress towards the therapeutic and safe management of their activities. It focuses on the possible pharmacological targeting of LXRs to cure or prevent selected skin diseases.
Fichier non déposé

Dates et versions

hal-01939752 , version 1 (29-11-2018)

Identifiants

Citer

Zangbewende Guy Ouedraogo, Allan Fouache, Amalia Trousson, Silvere Baron, A. Lobaccaro. Role of the liver X receptors in skin physiology: Putative pharmacological targets in human diseases.. Chemistry and Physics of Lipids, 2017, 207 (Pt B), pp.59-68. ⟨10.1016/j.chemphyslip.2017.02.006⟩. ⟨hal-01939752⟩
18 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More