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Article Dans Une Revue Steroids Année : 2015

Enolase is regulated by Liver X Receptors.

Résumé

Enolase is a glycolytic enzyme known to inhibit cholesteryl ester hydrolases (CEHs). Cholesteryl ester loading of macrophages, as occurs during atherosclerosis, is accompanied by increased Enolase protein and activity. Here, we describe that J774 macrophages treated with LXR agonists exhibit reduced Enolase transcript and protein abundance. Moreover, we show that this reduction is further potentiated by activation of the LXR/RXR heterodimer with the RXR ligand 9-cis retinoic acid. Enolase levels are also reduced in vivo following activation of LXRs in the intestine, but not in the liver. This effect is lost in Lxralphabeta-/- mice. In aggregate, our study identified Enolase as a new target of LXRs in vivo, which may promote cholesterol mobilization for subsequent efflux.
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Dates et versions

hal-01925151 , version 1 (16-11-2018)

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Hugues de Boussac, Salwan Maqdasy, Amalia Trousson, Noam Zelcer, H. Volle, et al.. Enolase is regulated by Liver X Receptors.. Steroids, 2015, 99 (Pt B), pp.266--71. ⟨10.1016/j.steroids.2015.02.010⟩. ⟨hal-01925151⟩
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