New Insights in Prostate Cancer Development and Tumor Therapy: Modulation of Nuclear Receptors and the Specific Role of Liver X Receptors - Université Clermont Auvergne Accéder directement au contenu
Article Dans Une Revue International Journal of Molecular Sciences Année : 2018

New Insights in Prostate Cancer Development and Tumor Therapy: Modulation of Nuclear Receptors and the Specific Role of Liver X Receptors

Résumé

Prostate cancer (PCa) incidence has been dramatically increasing these last years in westernized countries. Though localized PCa is usually treated by radical prostatectomy, androgen deprivation therapy is preferred in locally advanced disease in combination with chemotherapy. Unfortunately, PCa goes into a castration-resistant state in the vast majority of the cases, leading to questions about the molecular mechanisms involving the steroids and their respective nuclear receptors in this relapse. Interestingly, liver X receptors (LXRα/NR1H3 and LXRβ/NR1H2) have emerged as new actors in prostate physiology, beyond their historical roles of cholesterol sensors. More importantly LXRs have been proposed to be good pharmacological targets in PCa. This rational has been based on numerous experiments performed in PCa cell lines and genetic animal models pointing out that using selective liver X receptor modulators (SLiMs) could actually be a good complementary therapy in patients with a castration resistant PCa. Hence, this review is focused on the interaction among the androgen receptors (AR/NR3C4), estrogen receptors (ERα/NR3A1 and ERβ/NR3A2), and LXRs in prostate homeostasis and their putative pharmacological modulations in parallel to the patients’ support.
Fichier principal
Vignette du fichier
ijms-19-02545.pdf (1.21 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-01922077 , version 1 (11-06-2021)

Licence

Paternité

Identifiants

Citer

Laura Bousset, Amandine Rambur, Allan Fouache, Julio Bunay, Laurent Morel, et al.. New Insights in Prostate Cancer Development and Tumor Therapy: Modulation of Nuclear Receptors and the Specific Role of Liver X Receptors. International Journal of Molecular Sciences, 2018, 19 (9), ⟨10.3390/ijms19092545⟩. ⟨hal-01922077⟩
93 Consultations
94 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More