A library of heptyl mannose-functionalized copolymers with distinct compositions, microstructures and neighboring non-sugar motifs as potent antiadhesives of type 1 piliated E. coli - Université Clermont Auvergne Accéder directement au contenu
Article Dans Une Revue Polymer Chemistry Année : 2016

A library of heptyl mannose-functionalized copolymers with distinct compositions, microstructures and neighboring non-sugar motifs as potent antiadhesives of type 1 piliated E. coli

Résumé

A large library of mannosylated copolymers having tunable compositions, microstructures and pendant motifs neighboring mannose of distinct nature were synthesized by combining (i) sequential, batch or semi-batch RAFT (co) polymerizations of glycidyl methacrylate (GMA) and N-[7-(alpha-D-mannopyranosyloxy) heptyl] methacrylamide (HMM) and (ii) epoxy-amine post-modifications with ethanolamine, (2-amino-ethyl) trimethylammonium chloride or taurine. Examination of the anti-adhesive properties against type 1 piliated E. coli allowed for identifying copolymers among the three series of post-modified glycopolymers capable of efficiently inhibiting bacterial adhesion at 0.1 and 1 mu M (on a mannose unit basis) in pre and post-incubation adhesion assays respectively.
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Dates et versions

hal-01396465 , version 1 (14-11-2016)

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Xibo Yan, Adeline Sivignon, Nicolas Barnich, Sébastien G Gouin, Julie Bouckaert, et al.. A library of heptyl mannose-functionalized copolymers with distinct compositions, microstructures and neighboring non-sugar motifs as potent antiadhesives of type 1 piliated E. coli. Polymer Chemistry, 2016, 7 (15), pp.2674-2683. ⟨10.1039/c6py00118a⟩. ⟨hal-01396465⟩
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