Photochemical Fate and Eco-genotoxicity Assessment of the Drug Etodolac. - Université Clermont Auvergne Accéder directement au contenu
Article Dans Une Revue Science of the Total Environment Année : 2015

Photochemical Fate and Eco-genotoxicity Assessment of the Drug Etodolac.

Résumé

The photochemical behavior of etodolac was investigated under various irradiation conditions. Kinetic data were obtained after irradiation of 10− 4 M aqueous solutions by UVB, UVA and direct exposure to sunlight. The Xenon lamp irradiation was used in order to determine the photodegradation quantum yield under sun-simulated condition (ϕsun). The value was determined to be = 0.10 ± 0.01. In order to obtain photoproducts and for mechanistic purposes, experiments were carried out on more concentrated solutions by exposure to sunlight and to UVA and UVB lamps. The drug underwent photooxidative processes following an initial oxygen addition to the double bond of the five membered ring and was mainly converted into a spiro compound and a macrolactam. Ecotoxicity tests were performed on etodolac, its photostable spiro derivative and its sunlight irradiation mixture on two different aquatic trophic levels, plants (algae) and invertebrates (rotifers and crustaceans). Mutagenesis and genotoxicity were detected on bacterial strains. The results showed that only etodolac had long term effects on rotifers although at concentrations far from environmental detection values. A mutagenic and genotoxic potential was found for its derivative.

Domaines

Chimie

Dates et versions

hal-01204887 , version 1 (24-09-2015)

Identifiants

Citer

Monica Passananti, Margherita Lavorgna, Maria Rosaria Iesce, Marina Dellagreca, Marcello Brigante, et al.. Photochemical Fate and Eco-genotoxicity Assessment of the Drug Etodolac.. Science of the Total Environment, 2015, 518-519, pp.258-265. ⟨10.1016/j.scitotenv.2015.03.009⟩. ⟨hal-01204887⟩
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