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Article Dans Une Revue Biochimica et Biophysica Acta - Molecular Basis of Disease Année : 2011

Liver X receptors, lipids and their reproductive secrets in the male

Résumé

Liver X receptor (LXR) a and LXRb belong to the nuclear receptor superfamily. For many years they have been called orphan receptors, as no natural ligand was identified. In the last decade the LXR natural ligands have been shown to be oxysterols, molecules derived from cholesterol. While these nuclear receptors have been abundantly studied for their roles in the regulation of lipid metabolism, it appears that they also present crucial activities in reproductive organs such as testis and epididymis, as well as prostate. Phenotypic analyses of mice lacking LXRs (−/−) pointed out their physiological activies in the various cells and organs regulating reproductive functions. This review summarizes the impact of LXR-deficiency in male reproduction, highlighting the novel information coming from the phenotypic analyses of −/−, −/− and −/− mice.
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Dates et versions

hal-00706536 , version 1 (11-06-2012)

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Fatim-Zorah El-Hajjaji, Abdelkader Oumeddour, Aurélien Pommier, Aurélia Ouvrier, Emilie Viennois, et al.. Liver X receptors, lipids and their reproductive secrets in the male. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2011, 1812 (8), pp.974. ⟨10.1016/j.bbadis.2011.02.004⟩. ⟨hal-00706536⟩
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