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Article Dans Une Revue Cell Metabolism Année : 2012

The missing link: Mul1 signals mitophagy and muscle wasting

Résumé

FoxO3 regulates the transcription of autophagy-related genes that induce mitophagy in muscle wasting. In this issue of Cell Metabolism, Lokireddy et al. (2012) now show that the mitochondrial ubiquitin protein ligase 1 (Mull) polyubiquitinates the mitochondrial fusion protein Mfn2 and is necessary for FoxO3- and lysosomal-dependent mitophagy in muscle atrophy.

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Dates et versions

hal-02651335 , version 1 (29-05-2020)

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Didier Attaix, Daniel Taillandier. The missing link: Mul1 signals mitophagy and muscle wasting. Cell Metabolism, 2012, 16 (5), pp.551-552. ⟨10.1016/j.cmet.2012.10.013⟩. ⟨hal-02651335⟩
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