Team MuSE, UMR MICALIS

The generation of variation in the DNA sequence of genomes is a prerequisite for adaptation. Our work focuses on the generation of genetic variation and its consequences at the single-cell level, in phages and bacteria.

Our approach is interdisciplinary and involves the development of new tools that combine genetics, molecular biology, fluorescent microscopy, optogenetics, microfluidics, image analysis and modelling.

Last publications

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  Muriel Andrieu, Christophe Brun, Nathalie Delgehyr, Blandine de Geyer, Marianne De Paepe, et al.. Comment réduite l'empreinte plastique de la recherche ?. Colloque du GDR Labos 1point5, Nov 2024, Paris, France. ⟨hal-04742189⟩
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  Chiara Enrico Bena, Jean Ollion, Marianne De Paepe, Magali Ventroux, Lydia Robert, et al.. Real-time monitoring of replication errors’ fate reveals the origin and dynamics of spontaneous mutations. Nature Communications, 2024, 15 (1), pp. 2702. ⟨10.1038/s41467-024-46950-0⟩. ⟨hal-04531840⟩
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  Marianne de Paepe, Laurent Jeanneau, Jerôme Mariette, Olivier Aumont, André Estevez-Torres. Purchases dominate the carbon footprint of research laboratories. PLOS Sustainability and Transformation, 2024, 3 (7), pp.e0000116. ⟨10.1371/journal.pstr.0000116⟩. ⟨hal-04666497⟩
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  Alice Grob, Chiara Enrico Bena, Roberto Di Blasi, Daniele Pessina, Matthew Sood, et al.. Mammalian cell growth characterisation by a non-invasive plate reader assay. Nature Communications, 2024, 15 (1), pp. 57. ⟨10.1038/s41467-023-44396-4⟩. ⟨hal-04392382⟩
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  Magali Ventroux, Salomé Baltzinger, Lucas Du Breuil, Marina Elez, Marianne De Paepe. DNA methylation levels and spontaneous mutations in Escherichia coli lambda phage. Phages in Lyon 2023, Nov 2023, Lyon, France. ⟨hal-04321532⟩

References

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